Major organs were weighed and adrenal, aorta, bladder, brain, caecum, colon, duodenum, eye, Harderian gland, heart, ileum, kidney, liver, lung, lymph node, mammary, muscle, nerve, oesophagus, ovary, pancreas, pituitary, prostate, rectum, salivary, seminal vesicles, spinal cord, spleen, stomach, testis, thymus, thyroid, trachea, uterus and vagina were investigated for non‐neoplastic and neoplastic findings. Rats were observed on a daily basis for abnormalities of appearance and behaviour or signs of ill‐health and weighed regularly throughout the study (first day of treatment; first week; every fortnight during the first year and every month for the remainder of the study). *Please select more than one item to compare Sodium ferrocyanide is usually produced from calcium ferrocyanide by treatment of the latter with sodium carbonate or sodium chloride, or from spent iron oxides of coal gas purifiers by boiling the spent iron oxide with lime and leaching the soluble calcium ferrocyanide therefrom and converting it to sodium ferrocyanide by treatment with a sodium salt. SCF/CS/ADD/GEN/26 Final. No adverse effects known for use in food. No adverse renal effects were seen at histopathological examination, other than a slight increase in incidence and severity of glomerulonephrosis in males in the first interim study. This complex ion partially dissociates according to its dissociation constant (K d = 10 −24) to produce the Fe 2+ ion and the cyanide ion, which at the pH of wine is found in high proportion as hydrogen cyanide. In humans, absorption was 0.25–0.42% (Nielsen et al., 1990b). This effect was seen in both males and females, although it was not consistent and inter‐animal variation in the parameter was frequently large. Please request a quote above to receive pricing information based on your specifications. Use is very limited, partly due to the strong yellow colour. After about five minutes of centrifugation, it is said that every 0.1 ml of precipitate represents 1% albumin. TOX 94/45, Why is there cyanide in my table salt? Any queries (other than missing content) should be directed to the corresponding author for the article. Specifications for sodium, potassium and calcium ferrocyanide have been defined in the EU in Commission Regulation (EU) No 231/2012 and also by JECFA (2006). Urine collected over a 2‐h period immediately following an oral water load of 25 mL/kg was analysed for volume, specific gravity and cell content. 14C was measured in expired air during the first 24 h after administration. 997 sodium ferrocyanide products are offered for sale by suppliers on Alibaba.com, of which other inorganic salts accounts for 7%, organic salt accounts for 3%, and pharmaceutical intermediates accounts for 2%. Read about company. Stability and reactivity Reactive Hazard None known, based on information available Stability No information available. Via Carlo Magno 1A, 43126 Data on surveys and methodologies used for the estimation of salt intake and the exposure assessment of ferrocyanides (E 535–538) are presented in Appendix, EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), I have read and accept the Wiley Online Library Terms and Conditions of Use, Genotoxicity testing of two anticaking agents: sodium and potassium ferrocyanide, Estimating 24‐hour urinary sodium excretion from casual urinary sodium concentrations in Western populations: the INTERSALT study, Potassium and Sodium Ferrocyanides. Potassium ferrocyanide is of low acute oral toxicity. Molecular Weight 484.06 . Treatment‐related effects were observed in kidneys (higher organ weight, tubular damage and granular and calcified deposits) in rats given 0.5% and 5% sodium ferrocyanide (450 and 4,500 mg/kg bw per day) in the diet for 13 weeks (Oser, 1959; cited in JECFA (1975)). Sodium and potassium ferrocyanide were tested for genotoxicity in human lymphocyte cells in an in vitro Comet assay (Basu et al., 2013). The amount of expired 14C (mean ± SD) during 24 h after gastric intubation was 0.04 ± 0.01% of administered dose. Submitted to EFSA on 30 November 2017. At a temperature of 20 degrees celsius, the solubility of potassium ferricyanide in water is known to be approximately equal to 464 grams per litre. However, The Panel considered none of the inadequacies large enough to invalidate the study. Extensive Literature search covering from January 1990 up to May 2018. Sodium ferrocyanide is the sodium salt of the coordination compound of formula [Fe(CN)6]4−. MBM Foods Recommended for consumption by children - maybe . The cyanide ligands are tightly bound to the iron, so it is not as toxic as simple inorganic cyanide salts. Sodium Chromate Cr-51 is a radiopharmaceutical providing radioactive chromium-51 in the form of sodium chromate for diagnostic usage. European Salt Producers’ Association (EU_SALT), 2017. in the refined exposure scenario estimated exposure to ferrocyanides (E 535–538) would correspond approximately to 0.003 mg ferrocyanide ion/kg bw per day in children and adolescents; absorption of ferrocyanides from the gastrointestinal tract was low, and there is no accumulation in human; ferrocyanides are of low acute toxicity and not mutagenic or carcinogenic; reproductive studies were not available, but a NOAEL of 1,000 mg sodium ferrocyanide/kg bw per day (highest dose tested) was identified from a prenatal developmental toxicity study; the kidney is the target organ for ferrocyanides toxicity as characterised by the high number of cells excreted in the urine in rats; 4.4 mg sodium ferrocyanide/kg bw per day was identified as the NOAEL for this effect in a chronic (2‐year) study in rats; assuming that the toxicity of this compound is due to the ferrocyanide ion only, the Panel established a ADI for ferrocyanide ion of 0.03 mg/kg bw per day; ferrocyanides (E 535–538) are only permitted as food additives in two food categories. Increased DNA damage was reported in an in vitro indicator assay with potassium but not sodium ferrocyanide at high doses. Full post‐mortems and histopathological examination of heart, kidney, liver, lung and spleen was carried out on all rats. Appendix B can be found in the online version of this output (‘Supporting information’ section). Conditions to Avoid Incompatible products. Combined compendium of food additive specifications, Comparisons of spot vs 24‐h urine samples for estimating population salt intake: validation study in two independent samples of adults in Britain and Italy, Rec assay and mutagenicity studies on metal compounds, A simple method for estimating 24 h urinary sodium and potassium excretion from second morning voiding urine specimen in adults, Determination of Free Cyanide in Ferrocyanides and Ferricyanides, Determination of potassium ferrocyanide in foods by resonance Rayleigh scattering method with basic triaminotriphenylmethane dyes, Determination of potassium ferrocyanide in foods by resonance Rayleigh scattering method with double‐charged triaminotriphenylmethane dyes, Assessment of dietary sodium intake using a food frequency questionnaire and 24‐hour urinary sodium excretion: a systematic literature review, Influences of potassium ferrocyanide on lipid oxidation of salted cod (Gadus morhua) during processing, storage and rehydration, Bioavailability of iron and cyanide from 59Fe‐ and 14C‐labelled hexacyanoferrates(II) in rats, Bioavailability of iron and cyanide from oral potassium ferric hexacyanoferrate(II) in humans, Mutagenic activities of metal compounds in bacteria, Study of the genotoxic potential of 48 inorganic derivatives with the SOS chromotest, Dissociation constants of inorganic acids and bases in aqueous solutions, The determination of ferrocyanide and related compounds in commercial sodium chloride, Reports from the Scientific Committee for Food (25th series). Sodium ferrocyanide decahydrate Revision Date 23-Jan-2018 10. The cyanide ligands are tightly bound to the iron, so it is not as toxic as simple inorganic cyanide salts. Submitted to EFSA on 25 November 2017. Ornua, 2017. No treatment‐related effects were observed in appearance, behaviour, body weight change, physical condition, urinary pathology, haematology, biochemical parameters, or gross and histopathology. Potassium ferrocyanide was reported to be negative at concentrations ranging from 5 to 500 mM when tested for mutagenicity in a Rec‐assay system with B. subtilis strains H17 and M45 (Kanematsu et al., 1980). Chemistry, Risk and Management, Simple, rapid and sensitive determination of hexacyanoferrate(II) (ferrocyanide) in salts by flow injection system utilizing anion exchange column as an integrated field for sensitive detection reaction and sepration/preconcentration, https://www.efsa.europa.eu/en/consultations/call/170811, http://www.efsa.europa.eu/en/food-consumption/comprehensive-database, https://www.efsa.europa.eu/en/data/call/170223, https://www.efsa.europa.eu/en/consultations/call/170929, http://cot.food.gov.uk/pdfs/cotcomcocannualreport1994.pdf, http://www.fao.org/food/food-safety-quality/scientific-advice/jecfa/jecfa-additives/en/, https://doi.org/10.1016/j.numecd.2013.06.011, http://www.ncbi.nlm.nih.gov/pubmed/2400471, http://www.ncbi.nlm.nih.gov/pubmed/805366, http://www.ncbi.nlm.nih.gov/pubmed/3118206, https://doi.org/10.1016/j.foodchem.2017.07.070, Content not less than 99.0% of the respective ferrocyanide, Not less than 99.0% of the respective ferrocyanide, Yellow crystals or crystalline powder for sodium and calcium ferrocyanides; lemon yellow crystals for potassium ferrocyanide, Passes test of the respective ferrocyanide, All soluble in water; sodium and potassium ferrocyanides insoluble in ethanol, Use of urinary excretion studies for the assessment of salt intake, Sodium intake data: different methodologies/representativeness, Sodium intake does not only originate from salt, Use of standard body weights for the exposure assessment, Assumption that all salt contains the additives while the Mintel's GNPD indicates that only 13% of the salt products in the database contain ferrocyanides (E 535 and E 536), Salt substitutes partly considered in the exposure assessment (only their sodium content is taken into account), Assumption that reported use levels were expressed as anhydrous ferrocyanide salts. WHO Food Additives Series, 70.36, Specifications for the identity and purity of food additives and their toxicological evaluation. Ferrocyanide was detected in liver, spleen, kidney and heart/lungs. (Retain the mixture for the Test for calcium). Male adrenal and female pituitary gland weights were higher at the 5% level. 3H2O in a single dose of 10 mg per animal by gastric intubation (Nielsen et al., 1990a). WHO Technical report series No. In particular, no treatment‐related effects were observed in kidneys of rats given 0, 4.5, 45 or 450 mg sodium ferrocyanide/kg bw per day, for either 49 weeks or 2 years (COT, 1994b). sodium and potassium ferrocyanide. Performance & security by Cloudflare, Please complete the security check to access. Neither the SCF (1991) nor JECFA (1970a, 1974a, 1975) have described any data on chronic toxicity and carcinogenicity of sodium, potassium or calcium ferrocyanide. Rats (both sexes) from the highest dose group drank more water compared to the controls and the other two dose groups during part of the first 9 months of the study. OJ L 83, 22.3.2012, p 1. You may need to download version 2.0 now from the Chrome Web Store. WHO Technical report series No. Data on usage levels of potassium ferrocyanide (E 536) and calcium ferrocyanide (E 538) in foods in response to the EFSA call for food additives usage level and/or concentration data in food and beverages intended for human consumption (Batch 6), Published 23 February 2017. Beagles (4 animals/sex per group) were given 0, 10, 100 or 1,000 mg/kg sodium ferrocyanide in the diet (equivalent to 0, 0.25, 2.5 and 25 mg/kg bw per day) for 13 weeks (unpublished data from Morgaridge (1970), cited in JECFA (1975)). Publication year. If you are at an office or shared network, you can ask the network administrator to run a scan across the network looking for misconfigured or infected devices. Get contact details and address| ID: 8029101233 Submitted in November 2013. However, this compound can release hydrogen cyanide gas upon reaction with acids. 10H 2 O . Likewise, following an oral dose of 500 mg (6.2–7.1 mg/kg‐bw) of potassium ferric ferrocyanide in humans (n = 3, male), absorption was 0.25%–0.42% of the FeII and FeIII, respectively, and whole body retention after seven days was 0.03–0.07% (Nielsen et al., 1990b). No data were submitted to EFSA following a public call for data. WHO Food Additives Series NO.5, Toxicological evaluation of certain food additives with a review of general principles and of specifications. EFSA Scientific Panel on Food Additives and Nutrient Sources added to Food, British Industrial Biological Research Association, UK Committees on the Toxicity of Chemicals in Food, Consumer Products and the Environment, European Inventory of Existing Chemical Substances, Food and Agriculture Organization of the United Nations, Joint FAO/WHO Expert Committee on Food Additives, EFSA Panel on Dietetic Products, Nutrition and Allergies, Organisation for Economic Co‐operation and Development, Scientific Committee for Animal Nutrition, is a publishing series for results of the often research‐based work that working groups or projects under Nordic Council of Ministers have put in motion. The potassium salt is produced by reacting sodium ferrocyanide with calcium hydroxide and potassium chloride and carbonate according to the following reactions: The ANS Panel decided to take into account all surveys from the NDA opinion in the current assessment. Sodium, potassium and calcium ferrocyanide (E 535, 536 and 538) are anticaking agents authorised as food additives in the EU, previously evaluated by JECFA several times, the latest in 1974 (JECFA, 1975) and the SCF in 1990 (SCF, 1991). Wego supplies Sodium Ferrocyanide Decahydrate to users/customers for Flame Retardants, Food & Beverage, Industrial Chemicals, Metal Working, Finishing & Flux, Mining - Salts & Metals. Parma, Italy. van Hees, R.P.J. Analytical LASER submitted in May 2018. Neither the SCF (1991) nor JECFA (1970a, 1974a, 1975) have described any data on genotoxicity of sodium, potassium or calcium ferrocyanide. Test for calcium (Vol. A wide variety of sodium ferrocyanide options are available to you, such as medicine grade, food grade, and industrial grade. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, Simplified structural formula of potassium ferrocyanide (anhydrous form), As reported by Wong‐Chong and co‐workers (. A dark blue precipitate is formed. Another way to prevent getting this page in the future is to use Privacy Pass. SODIUM FERROCYANIDE is a coordination compound of iron. 46A. If actual practice changes this refined estimates may no longer be representative and should be updated. The compounds were tested at concentrations of 0, 1, 5 and 10 mM for 3 h. The tail DNA (%) (± SEM) was increased after treatment with potassium ferrocyanide at 5 mM (3.55 ± 0.12) and 10 mM (4.22 ± 0.5) mM when compared to control (2.16 ± 0.15) (p ≤ 0.05). Find here Sodium Ferrocyanide, Na4FeC6N6 manufacturers, suppliers & exporters in India. Free iron was detected in erythrocytes and free cyanide was detected in urine and expired air. He was deeply unconscious and unresponsive to painful stimuli. However, in the 2‐year study, mid‐ and high dose animals frequently showed a higher cell excretion rate in 2‐h urine samples than did controls. The difference was not statistically significant and in the absence of any associated lesions and the small number of fetuses affected it was concluded by COT (1994b) that a relationship to treatment was considered not to have been proved. Overall, there were no reproductive studies available and in one prenatal developmental toxicity study in rats (as cited in COT, 1994b) a NOAEL of 1,000 mg sodium ferrocyanide/kg bw per day (the highest dose tested) was identified. Although many salts of cyanide are highly toxic, food-grade forms of ferrocyanide are far less toxic because they do not release free cyanide. If you are on a personal connection, like at home, you can run an anti-virus scan on your device to make sure it is not infected with malware. Addn of sodium ferrocyanide soln to slightly acidic soln of iron salts causes pptn of insol prussian blue (ferric ferrocyanide), Fe4[Fe(CN)6)]3. Sodium ferrocyanide forms gels with heavy metals in general. Please check your email for instructions on resetting your password. The average daily intakes of sodium ferrocyanide were estimated to be equal to 0, 4.4, 45 or 450.7 mg/kg bw per day for males and 0, 6.2, 62.5 or 630.1 mg/kg bw per day for females given 0, 50, 500 or 5,000 mg/kg sodium ferrocyanide in the diet. Blood was sampled at the end of the study and analysed for total RBC and WBC counts, differential WBC count, haemoglobin concentration, PCV and reticulocyte count. The Panel further noted that it was a pre‐GLP study, but that the BIBRA GLP Unit audited the study to ensure that the results accurately reflects the raw data generated during the study. Blood was sampled during weeks 14, 26 and 54 from 12 rats/sex from the 0, 500 and 5,000 mg/kg groups and from all surviving rats sacrificed at the end of the study. There was a statistically significant increase in the mean number of cells excreted per hour in 2‐h urine samples of treated animals (both sexes) from the 500 and 5,000 mg/kg groups compared with controls (males: 683, 533, 1,517 and 4,000; females 250, 418, 4,200 and 4,782 in the 0, 50, 500 and 5,000 mg/kg groups, respectively). The Panel also noted that the refined exposure estimates are based on information provided on the reported level of use of ferrocyanides (E 535–538). Its EINECS registry number is 237-081-9. Study of the possible application of sodium ferrocyanide for the prevention of sodium chloride damage in building materials. No treatment‐related effects were observed in dogs given dietary sodium ferrocyanide up to 1,000 mg/kg (25 mg/kg bw per day) for 13 weeks (Unpublished data from Morgaridge (1970), cited in JECFA (1975). To assess the dietary exposure to ferrocyanides (E 535–538) from their use as food additives, the exposure was calculated based on (1) MPL in FC 12.1.1 ‘Salt’ set out in the EU legislation (defined as the regulatory maximum level exposure assessment scenario) and (2) the mean reported use levels of salt (defined as the refined exposure assessment scenario). Geneva, Switzerland, Monograph 1. Potassium ferrocyanide was absorbed to a limited extent from the gastrointestinal tract following oral administration to rats (Gage (1950), cited in JECFA). Data on usage levels of sodium ferrocyanide (E 535) and potassium ferrocyanide (E 536) in foods in response to the EFSA call for food additives usage level and/or concentration data in food and beverages intended for human consumption (Batch 6), Published 23 February 2017. 539, FAO nutrition meeting report series No.53, Evaluation of certain food additives. Rats (10 animals/sex per group) were given 0%, 0.05%, 0.5% or 5% sodium ferrocyanide in the diet for 13 weeks (equivalent to 0, 45, 450 and 4,500 mg/kg bw per day using the EFSA default value of 0.09 for subchronic studies (EFSA, 2012)) (unpublished study by Oser (1959), cited in JECFA (1975)) Slightly lower growth rate and food consumption was observed at the 5% level. The effect was more marked at the 5% level where granular and calcified deposits were observed The Panel noted that the ADI set by JECFA for sodium, potassium and calcium ferrocyanide was based on this study. Total 14C‐activity (mean ± SD) in urine after 7 days was 2.8 ± 0.5% of dose. Part 2: general principles, Guidance on selected default values to be used by the EFSA Scientific Committee, Scientific Panels and Units in the absence of actual measured data, Scientific Opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC), Statement on the applicability of the Margin of Exposure approach for the safety assessment of impurities which are both genotoxic and carcinogenic in substances added to food/feed, Opinion of the Scientific Committee for Animal Nutrition on the safety of potassium and sodium ferrocyanide used as anticaking agents, Pooled results from 5 validation studies of dietary self‐report instruments using recovery biomarkers for potassium and sodium intake, The influence of anticaking agent potassium ferrocyanide and salt on the oxidative stability of frozen minced pork meat, Toxicological evaluation of some food colours, emulsifier, stabilizers, anti‐caking agents and certain other substances. There were higher incidences of pneumonia in male rats from the 5,000 mg/kg group (20/48 animals, p < 0.01) and of emphysema in both the 500 and 5,000 mg/kg groups (7/48 animals, p < 0.01 and 13/48 animals, p < 0.001, respectively) compared to control. Completing the CAPTCHA proves you are a human and gives you temporary access to the web property. Sodium ferrocyanide (E 535) According to Commission Regulation (EU) 231/201210 10 Commission Regulation (EU) No 231/2012 of 9 March 2012 laying down specifications for food additives listed in Annexes II and III to Regulation (EC) no 1333/2008 of the European Parliament and of the Council. Potassium ferrocyanide was reported to be negative at a concentration of 2.5 mM when tested for mutagenicity in a Rec‐assay system with Bacillus subtilis strains H17 and M45 (Nishioka, 1975). The Panel noted that no analyses were carried out to verify the concentrations of ferrocyanide in the various diets. Free iron was detected in erythrocytes and free cyanide was detected in urine and expired air. Technical University of Denmark (DTU). Get best price and read about company. Total 59Fe‐activity (mean ± SD) in faeces and urine after 7 days was 94.4 ± 2.9% and 2.5 ± 0.8% of dose, respectively. The erythrocyte incorporation (mean ± SD) of 59Fe was 0.005 ± 0.0007% of the dose. Overall, treatment‐related effects were observed in kidneys (higher organ weight, tubular damage and granular and calcified deposits) in rats given 0.5% and 5% sodium ferrocyanide (450 and 4,500 mg/kg bw per day) in the diet for 13 weeks (unpublished study by Oser (1959), cited in JECFA (1975)). Get contact details & address of companies manufacturing and supplying Sodium Ferrocyanide, Na4FeC6N6, 13601-19-9 across India. Subject: sodium ferrocyanide? Potassium ferrocyanide significantly reduced cell viability at all tested concentrations for about 20% compared to control, whereas sodium ferrocyanide significantly reduced cell viability for approximately 17% at the highest tested concentration only (10 mM). The majority was excreted unchanged in the faeces (approximately 95% of the dose). National Hazard. Sodium ferrocyanide is the sodium salt of the coordination compound of formula [Fe(CN)6]4−. Data on usage levels of sodium ferrocyanide (E 535) in foods in response to the EFSA call for food additives usage level and/or concentration data in food and beverages intended for human consumption (Batch 6), Published 23 February 2017. Sodium, potassium and calcium ferrocyanide were evaluated by JECFA in 1969, 1973 and 1974. Overall, no carcinogenic effect was seen in these studies and neither were there any non‐neoplastic findings observed considered to be of toxicological relevance. No treatment‐related effects were observed in dogs given dietary sodium ferrocyanide up to 25 mg/kg bw per day for 13 weeks (Morgaridge, 1970; cited in JECFA (1975)). Food and water intake were recorded approximately once a fortnight (first year) and at monthly intervals (second year). No clinical biochemistry parameters were measured and several organs were missing for histopathological examination. Based on the available data, the Panel considered that the use of ferrocyanides as food additives is not of genotoxic concern. Haematocrit and haemoglobin values were lower at the 5% level. Blood was analysed for total red blood cell (RBC) and white blood cell (WBC) counts, differential WBC count (0 and 5,000 mg/kg groups only), haemoglobin concentration, packed cell volume (PCV) and reticulocyte count (0 and 5,000 mg/kg groups only). 12 July 2001, Development and validation of HPLC method for the determination of ferrocyanide ion in food grade salts, Kirk‐Othmer Encyclopedia of Chemical Technology, Reproducibility of urinary biomarkers in multiple 24‐h urine samples, A simple method to estimate populational 24‐h urinary sodium and potassium excretion using a casual urine specimen, Food Additives in Europe 2000 ‐ Status of safety assessments of food additives presently permitted in the EU, Urinary excretion of sodium, potassium, and chloride, but not iodine, varies by timing of collection in a 24‐hour calibration study, Strategies to monitor and evaluate population sodium consumption and sources of sodium in the diet. Hindusthan Chemicals Company - Offering Sodium Ferrocyanide, Na4FeC6N6, 13601-19-9, tetrasodium hexacyanoferrate, yellow prussiate of soda, सोडियम फेरो साइनाइड, Sodium Ferrocyanide in Nariman Point, Mumbai, Maharashtra. : 13601-19-9 Purity: ≥98.00% 1 USD/Gram SHANDONG BELIEVE CHEMICAL PTE LTD Appendix A can be found in the online version of this output (‘Supporting information’ section). In humans, absorption was 0.25–0.42% (Nielsen et al., 1990b). WBR and total recovery of 59Fe (mean ± SD) was 0.09 ± 2.1 and 97 ± 2.1% of the dose, respectively. The Panel on Food Additives and Nutrient Sources added to Food (ANS) provided a scientific opinion re‐evaluating the safety of sodium ferrocyanide (E 535), potassium ferrocyanide (E 536), and evaluating the safety of calcium ferrocyanide (E 538) as food additives. se of acute self-induced poisoning using sodium ferrocyanide and methanol admitted to our hospital 2 hours after ingestion. There were no reproductive toxicity studies available and in one prenatal developmental toxicity study in rats (as cited in COT, 1994b) a NOAEL of 1,000 mg sodium ferrocyanide/kg bw per day (the highest dose tested) was identified. Ferrocyanide is a salt ion and comes mainly in three forms as a food additive: Sodium ferrocyanide, potassium ferrocyanide, and calcium ferrocyanide, with the first form being the most common. Elimination was > 97% and > 99% faecal in rats and humans, respectively. Compare Products: Select up to 4 products. Pre‐evaluation document on sodium, potassium and calcium ferrocyanide (E 535, 536 and 538). European Food Safety Authority, Overall, potassium ferrocyanide was absorbed to a limited extent from the gastrointestinal tract following oral administration to rats (unpublished data from Gage (1950), cited in JECFA (1975); Nielsen et al., 1990a). Title. However, this compound can release hydrogen cyanide gas upon reaction with acids. Based on the lowest NOAEL for this effect of 4.4 mg sodium ferrocyanide/kg bw per day for male rats, the Panel derived an ADI of 0.044 mg sodium ferrocyanide/kg bw per day. Posts: 311 Registered: 9-1-2012 Location: In your nation! … Assertion : Potassium ferrocyanide is diamagnetic whereas potassium ferricyanide is paramagnetic.